Investigation the Association of the VEGFR-2 and -2578C\A Polymorphism as a Risk Factor for Incidence of Lung Cancer in Babylon Province
Keywords:Lung cancer, VEGFR-2, polymorphism, dominant model.
Background: VEGF gene polymorphisms can induce either increase or inhibition of VEGF secretion, with
altered promoter activity.
Aim: We investigated the association of the VEGFR-2 and -2578C\A polymorphism in the VEGF gene with
Lung cancer risk in Babylon province. Methodology: VEGFR-2 level was measured by Enzyme Linked
Immunoabsorbant Assay ELISA and Genotyping of the VEGF-gene variation (-2578A\C) was performed
using the amplification refractory mutation system PCR. We investigated the association of VEGF gene
variants with different clinicopathological features of lung cancer patients.
Results: No significant difference was seen of the VEGFR-2 levels in lung cancer patients when compared
with control group (P=092), the allelic frequency of -2578 A\C VEGF gene no difference was seen in patients
lung cancer (p=0.652). Hardy-Weinberg equilibrium showed a significant difference cases group (p=0.016),
also revealed A allele exhibits a pathological behavior and it appears in over-dominant model (p=0.05), this
proves that there is significant association of -2578A\C VEGF gene in lung cancer patients.
Conclusion: Our results showed no significant association of the VEGFR-2 in lung cancer patients
while showed a significant association of the VEGF -2578C\A polymorphism with LC susceptibility in
Babylon province .The VEGF -2578C\A heterozygote significantly increases the risk and can be useful as a
predisposing genetic marker.
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