Investigation the Association of the VEGFR-2 and -2578C\A Polymorphism as a Risk Factor for Incidence of Lung Cancer in Babylon Province
DOI:
https://doi.org/10.37506/ijfmt.v14i3.10794Keywords:
Lung cancer, VEGFR-2, polymorphism, dominant model.Abstract
Background: VEGF gene polymorphisms can induce either increase or inhibition of VEGF secretion, with
altered promoter activity.
Aim: We investigated the association of the VEGFR-2 and -2578C\A polymorphism in the VEGF gene with
Lung cancer risk in Babylon province. Methodology: VEGFR-2 level was measured by Enzyme Linked
Immunoabsorbant Assay ELISA and Genotyping of the VEGF-gene variation (-2578A\C) was performed
using the amplification refractory mutation system PCR. We investigated the association of VEGF gene
variants with different clinicopathological features of lung cancer patients.
Results: No significant difference was seen of the VEGFR-2 levels in lung cancer patients when compared
with control group (P=092), the allelic frequency of -2578 A\C VEGF gene no difference was seen in patients
lung cancer (p=0.652). Hardy-Weinberg equilibrium showed a significant difference cases group (p=0.016),
also revealed A allele exhibits a pathological behavior and it appears in over-dominant model (p=0.05), this
proves that there is significant association of -2578A\C VEGF gene in lung cancer patients.
Conclusion: Our results showed no significant association of the VEGFR-2 in lung cancer patients
while showed a significant association of the VEGF -2578C\A polymorphism with LC susceptibility in
Babylon province .The VEGF -2578C\A heterozygote significantly increases the risk and can be useful as a
predisposing genetic marker.
Downloads
Published
Issue
Section
License
- The journal allows readers to read, download, copy, distribute, print, search, or link to the full texts of its articles and allow readers to use them for any other lawful purpose.
- The journal allows the author(s) to hold the copyright without restrictions.
- The journal allows the author(s) to retain publishing rights without restrictions