Some Histogenetic Aspects of Methotrexate Associated with Juvenile Idiopathic Arthritis (JIA) Treatment Doses

Authors

  • Asal A. Tawfeeq1 , Sundus M. Taifoor2

DOI:

https://doi.org/10.37506/ijfmt.v14i4.11584

Keywords:

Methotrexate, Kidney, DNA methylation, JIA, RAPD-PCR.

Abstract

A total of (36) mice in the age of (1-3) weeks were selected to evaluate the methotrexate effect on some
histogenetic aspects of kidneys. Treatment lasted for three months, and results showed marked hemorrhage,
cortical tubular basophilia, necroses, and degeneration in the autopsied organ of animals with low oral
hydration. Besides, changes in the DNA methylation pattern were noticed in the RAPD-PCR profile upon
analysis with agarose gel electrophoresis.

Author Biography

  • Asal A. Tawfeeq1 , Sundus M. Taifoor2

    1Assistant Professor, 2Lecturer, Northern Technical University/ Technical College of Kirkuk, Medical Laboratory
    Technique Department

Downloads

Published

2020-10-29

Issue

Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology

Section

Articles

License

https://creativecommons.org/licenses/by-nc/2.0/deed.en

How to Cite

Some Histogenetic Aspects of Methotrexate Associated with Juvenile Idiopathic Arthritis (JIA) Treatment Doses. (2020). Indian Journal of Forensic Medicine & Toxicology, 14(4), 782-787. https://doi.org/10.37506/ijfmt.v14i4.11584