Correlation of Toluene Safe Duration (Hours/Day) and Glutathione Concentration, Malondialdehyde and Neurotoxic Symptoms in Osowilangun Shoe Home Industry Workers

Authors

  • Diah Pramesthi Ningrum1 , Abdul Rohim Tualeka2 , Juliana Jalaludin3 , Syamsiar S Russeng4 , Pudji Rahmawati5 , Ahsan Ahsan6 , Indri H Susilowati7

DOI:

https://doi.org/10.37506/ijfmt.v14i4.11602

Keywords:

: Neurotoxic Symptoms, Glutathione, Safe Concentration, Malondialdehyde, Toluene

Abstract

Introduction: Exposure of toluene can cause a decrease in glutathione concentration, increase in
malondialdehyde and neurotoxic symptoms. The safe duration of toluene in hours/day for each person can
vary. The purpose of this study is to determine the relationship between the safe duration of toluene (hours/
day) with the concentration of glutathione, malondialdehyde and neurotoxic symptoms in Osowilangun
shoe home industry workers.
Methods: This research was observational with quantitative approach and cross-sectional design. The
sampling technique used was accidental sampling with 25 respondents. The variables studied were safe
toluene duration (hours/day), glutathione concentration, malondialdehyde concentration, and neurotoxic
symptoms. Data were analyzed using Pearson and Phi correlation.
Result: The average of safe duration was 1,489 hours/day, glutathione concentration was 58,349 µg/L,
and malondialdehyde was 7,847 MU. As many as 11 out of 14 workers experienced neurotoxic symptoms.
The relationship between safe duration (hours/day) with glutathione concentration (r=0.139) and
malondialdehyde (r=-0.146) was very weak. While, the relationship between safe duration (hours/day) and
neurotoxic symptoms was weak (?=-0.223).
Conclusion: The relationship between safe duration in hours/day with glutathione concentration and
malondialdehyde was very weak, while relationship with neurotoxic symptoms was weak.

Author Biography

  • Diah Pramesthi Ningrum1 , Abdul Rohim Tualeka2 , Juliana Jalaludin3 , Syamsiar S Russeng4 , Pudji Rahmawati5 , Ahsan Ahsan6 , Indri H Susilowati7

    Research Scholar, 2Professor, Department of Occupational Health and Safety, Public Health Faculty, Airlangga
    University, 60115, Surabaya, East Java, Indonesia, 3Professor, Department of Environmental and Occupational
    Health, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 UPM Serdang, Selangor,
    Malaysia, 4
    Professor, Department of Occupational Health and Safety, Faculty of Public Health, Hassanudin
    University, Makassar, Indonesia,5Professor, Department of Development of Islamic Society, State Islamic
    University Sunan Ampel, Surabaya, Indonesia 6
    Professor, Public Health Faculty, University of Indonesia, Depok,
    Indonesia, 7 Professor, Faculty of Nurse, Brawijaya University, Malang, Indonesia

Downloads

Published

2020-10-29

How to Cite

Correlation of Toluene Safe Duration (Hours/Day) and Glutathione Concentration, Malondialdehyde and Neurotoxic Symptoms in Osowilangun Shoe Home Industry Workers. (2020). Indian Journal of Forensic Medicine & Toxicology, 14(4), 868-874. https://doi.org/10.37506/ijfmt.v14i4.11602