Relation between Serum Lipids and Thyroid Hormones in Hypothyroidism Patients

Authors

  • Dheyaa Shinyar Hamad

DOI:

https://doi.org/10.37506/ijfmt.v14i4.11608

Keywords:

hypothyroidism, atherosclerosis, T4, TSH, non-HDL.

Abstract

Background: Hypothyroidism is a condition that occurs as a result of a malfunction in the thyroid glands
that leads to a decrease in the secretion of their main hormones. Thyroid hormones are known to be have
an important role in the regulating metabolism of lipids; thus, any impaired in the thyroid function causes
a significant change in the levels of lipid. Objective: To evaluate the changes occurs for lipid levels in
hypothyroidism patients and determine the correlation between lipids parameters and some thyroid hormones.
Materials and Methods: The study included 45 healthy control subjects and 52 hypothyroidism patients
who visited private doctors’ clinics in Basra, Iraq. Thyroid hormones and serum lipids were measured for
both healthy subjects and hypothyroidism patients. Results: The study indicates an increase in the thyroid
stimulating hormone (TSH) values for hypothyroidism patients as compared to the healthy control group
while there is a slightly difference in the values of each of triiodothyronine (T3) and thyroxine (T4) between
the two groups. There is a significant increase in the mean values of all lipids except for high density
lipoprotein (HDL) in the hypothyroidism patients compared to that in healthy control subjects. The study
presents that there is a positive correlation between TSH and all lipid parameters except for HDL which
gives negative relation (r = - 0.20). There is a moderate correlation between TSH and non-HDL (r = 0.42)
while the other lipids appear weak correlation (TC(r=0.14), TG (r=0.19). LDL (0.16), VLDL (0.17), and
LDL/HDL (0.17)). There is no correlation between T4 and TC (r = 0.03), LDL (r = 0.07). non-HDL (r =
0.04), and LDL/HDL (r = 0.06), HDL (r = - 0.02) while TG and VLDL appears weak correlation (r = -
0.11 to each one of them). Conclusions: The study found that the abnormal change in the levels of lipids
during hypothyroidism may increase the likelihood for occurrence of arteriosclerosis and the emergence of
cardiovascular disease in hypothyroidism patients. There is a moderate positive relationship between TSH
and non-HDL levels, as this indicates that non-HDL should be added to lipid profile tests as evidence of
measuring cardiac risk in patients with hypothyroidism

Author Biography

  • Dheyaa Shinyar Hamad

    Lecturer Community Health Technologies Department, Health and Medical Technologies College in Basrah,
    Southern Technical University, Iraq

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Published

2020-10-29

How to Cite

Relation between Serum Lipids and Thyroid Hormones in Hypothyroidism Patients. (2020). Indian Journal of Forensic Medicine & Toxicology, 14(4), 901-907. https://doi.org/10.37506/ijfmt.v14i4.11608