Evaluation of Storage Length to Blood Component Platelet Concentrate Quality in the Blood Bank, Dr. Soetomo General Hospital, Surabaya, Indonesia

Abstract

Storage of Platelet Concentrate (PC) can cause changes in thrombocyte quality that affect thrombocyte
viability and decrease hemostatic function. All biochemical, structural and functional changes to platelets
during storage in the Blood Bank are known as platelet storage lesions. To analyze the effect of storage
length on changes in thrombocyte morphology and function as well as the metabolic parameters of platelet
concentrate bag components. This was an analytical study with time series design. Sampling was done
consecutively. Samples were new PC bags which were processed and stored at room temperature with
agitation during June-July 2019 in the Blood Bank of the Dr. Soetomo General Hospital, Surabaya.
Examination of platelet count and MPV were performed to determine morphological changes and metabolic
parameters like pH, pCO2, and pO2 on day 1, day 3, and day 5th. Data were analyzed by using Shapiro-Wilk
test, Paired t test and Wilcoxon Signed Rank Test. There were significant changes in MPV, pH, and pCO2
values during storage (p <0.05). However, there were no significant changes in platelet count and pO2
value. Metabolic changes in PC bag were obtained but there was no decrease in platelet count so that the PC
component was still feasible to be given to the patient. Further research is needed for other parameters that
can be affected by the storage process.