Influence of Sesame Oil on Physiologic and Histopathological Changes in Alloxnized Male Guinea Pigs

Authors

  • Ahlam A. AL-Rikaby1, Mitham A. AL-Rikaby2 , Saleh K.Majeed3, Researcher/Hussein S. AL-Jaberi1

DOI:

https://doi.org/10.37506/ijfmt.v14i4.11759

Keywords:

Sesame oil, hemoglobin A1c, Malondialdehyde, Hormones, male pigs

Abstract

The current study was to investigate the effect sesame oil (Sesamum indicum L) on glycosylated hemoglobin,
blood glucose, Malondialdehyde, semen and hormonal parameters, in addition the histopathological
changes on pancreas in diabetic pigs. The physiological indices were examined in control, diabetic and oil
treated diabetic pigs. Eighteen male pigs were randomly assigned into three groups, group one as control,
group two diabetic as positive control and group three diabetic treatment with sesame oil at dose (1ml/kg)
orally, after 30 days whole blood samples were collected to measure the hemoglobin A1c and other samples
were separated into serum for blood glucose and MDA and hormonal assays. Epididymal taken for sperm
parameters examined, all animals were sacrificed and pancreas was taken for histological study. Outcomes
of this study indicate that significantly reduction in serum Malondialdehyde level in associated with lowered
levels of blood glucose and hemoglobin A1c, While, significantly elevation in serum testosterone, FSH
and LH levels accompanied with the improved spermatogenesis were observed in group treated with the
sesame oil. In addition, the a significant islet langer hans restoration was notable. Conclusion: The oil has
antioxidant and ameliorated effects on pancreatic function and markedly improved sperm profile.

Author Biography

  • Ahlam A. AL-Rikaby1, Mitham A. AL-Rikaby2 , Saleh K.Majeed3, Researcher/Hussein S. AL-Jaberi1

    1Department of Physiology, Pharmacology and Biochemistrym, College of Veterinary Medicine, University of
    Basrah, Iraq, 2
    Department of Clinical Pharmcology , College of Pharmacy, Univeristry Basrah, Iraq,
    3
    Department of Pathology , College of Veterinary Medicine, University of Basrah, Iraq

Downloads

Published

2020-10-29

How to Cite

Influence of Sesame Oil on Physiologic and Histopathological Changes in Alloxnized Male Guinea Pigs. (2020). Indian Journal of Forensic Medicine & Toxicology, 14(4), 1523-1529. https://doi.org/10.37506/ijfmt.v14i4.11759