Determination of IL17 Plasma Levels and IL-17A gene Polymorphisms in Patients with Allergic Rhinitis

Abstract

Aim: The present study aims to determine whether the level of serum interleukin -17 and IL-17 receptors (
IL-17A) gene variant increases or decreases susceptibility to Allergic Rhinitis. Method: In this case-control
study fifty patients with rhinitis and fifty apparently healthy persons as a control in Babylon province /
Iraq were enrolled in this study. Results: the results of this study were shown significant difference in
frequency of IL-17 A (rs2275913) A>G polymorphism between Rhinitis patients and controls .Also , there
were significant difference in frequency of IL-17A (rs 2275913) between rhinitis patients and controls and
there were significant increase in patient compared with control. Conclusion: The bpresent study suggests
that patients with AA allele for IL-17A (rs2275913) have increased susceptibility to rhinitis compared with
GG allele , Also the present study suggests that IL-17A (rs2275913) is considered risk factor for Allergic
Rhinitis. This study suggests that the level of IL-17 patients with rhinitis highly significant compared with
healthy.