Evaluation of Breast Cancer Molecular Profile in Old Age Patients in Comparison to Young Age Patients

Abstract

Background: Breast cancer is the commonest malignancy of females all over the world and the second
leading cause of death due to malignancy among females. Breast cancer is regarded as a unique disease in
oncology and the specific markers such as ER, PR, HER-2/neu and others are used to predict the prognosis
and the treatment response to guide the therapeutic plan.
Aim of the Study: To clarify if there is any significant difference in the intrinsic molecular profile of breast
cancer in old age patients in comparison to young age patients.
Material & Methods: Samples of primary carcinoma of breast, obtained from 211 female patients with
breast cancer. The patients are divided into two group. Immunohistochemical analysis was done for the
specimens by using Envision method for detection of estrogen receptor, progesterone receptor, Her2/neu.
Statistical analysis was done by using SPSS. In which we use frequency, percentage and mean as descriptive
statistics while chi square and Yates corrected chi square as analytic statistics.
Result: We found molecular intrinsic breast cancer subtypes have a significant difference in distribution
of elderly breast cancer compared to their younger counterparts where elderly patients more frequently
Luminal A and Luminal B tumor subtypes and less frequently HER2+ and basal molecular subtypes.
Conclusion old age breast cancer patients have better prognosis in comparison to young age patients
according to the biological profile, histopathological type and Immunohistochemical prognostic parameters.