Expression Studies of the Cancer Drug and Its Effect on Angiogenesis-Promoting Genes in Cancer Cell Lines

Authors

  • Salam Abbas1 , Noor Harith AL-Hamid

DOI:

https://doi.org/10.37506/ijfmt.v14i4.11806

Keywords:

HuR, Anticancer targets, HIF1 ?, Decetexal

Abstract

Objective: Being a member of RNA binding proteins, Human Antigen R (HuR) is considered as an acute
factor to mediate the proangiogenic factors causing the angiogenesis amongst tumor cells. All through the
anoxic conditions and inflammation, the cytokine IL-1 activated the HuR which further downregulated or
upregulated the hypoxia inducible factors (HIF1?). Current study was conducted to observe the correlative
impact of Decetexal (Taxotere) cancer drug on HIF? and HuR expression levels while utilizing the cell line
HeLa.

Author Biography

  • Salam Abbas1 , Noor Harith AL-Hamid

    Assi. Lect., Nursing technique Dept. Kufa Technical Institute, 31003 AAl-Furat Al-Awsat Technical University,
    kufa, Iraq, 2Assist. Lect. University of Baghdad -College of Science - Biotechnology Department/Iraq

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Published

2020-10-29

Issue

Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology

Section

Articles

License

https://creativecommons.org/licenses/by-nc/2.0/deed.en

How to Cite

Expression Studies of the Cancer Drug and Its Effect on Angiogenesis-Promoting Genes in Cancer Cell Lines. (2020). Indian Journal of Forensic Medicine & Toxicology, 14(4), 1809-1815. https://doi.org/10.37506/ijfmt.v14i4.11806