Role of Selective Cytokines in the Pathophysiology of Patients with Celiac Disease

Abstract

Background and Aims: Inflammatory cytokines levels may be elevated in patients with celiac disease
(CD). But little known about the association of these cytokines and some immunological parameters used
for diagnosis of celiac disease. This study aimed to evaluate the levels of some inflammatory cytokines in
patients with celiac disease and compare it with healthy individuals and then their association with some
immunological markers used for diagnosis of celiac disease.
Methods: A total of 60 patients with celiac disease and 40 healthy persons were enrolled in 2019. The
levels of Anti-tissue transglutaminase levels were measured for patients and healthy groups, also Tumor
necrosis factor Alpha (TNF-?), Interleukin-6 (IL-6) and Interleukin-8 (IL-8) were measured using enzymelinked immunosorbent assay techniques. Then compare these parameters between groups and the correlation
between these parameters were assessed.
Results: The mean levels of Tumor necrosis factor Alpha (TNF-?), Interleukin-6 (IL-6) and Interleukin-8
(IL-8) give a highly significant difference between patients and healthy groups. Anti-tissue transglutaminase
levels correlated and were show statistically significant with these cytokines.
Conclusions: TNF-?, IL-6 and IL-8 play a role in the pathophysiology of celiac disease.