Evaluating the Role of High Molecular Weight Adiponectin in Women with Polycystic Ovary Syndrome Treated with Omega-3 Fatty Acids

Abstract

Polycystic ovary syndrome (PCOS) is a significant health problem affecting women during the reproductive
age and characterized by hormonal disturbance resulting in irregular menstrual periods and infertility.
Adiponectin is a protein produced by adipocytes and involved in glucose and lipid metabolism. This study
included the evaluation of two doses of omega-3 (300 and 600mg/day for 14 weeks). Age, body mass
index (BMI), fasting blood glucose level, homeostatic model assessment (HOMA), lipid profile, luteinizing
hormone (LH), follicle-stimulating hormone (FSH), prolactin, estrogen and HMW adiponectin levels were
evaluated. Our data showed no significant differences between control group and treatment groups in BMI,
age, sex hormones, fasting blood glucose, and HOMA levels. However, the level of HMW adiponectin was
significantly higher in women treated with 600mg/day for 14 weeks (p < 0.0001) but not 300mg / day of
Omega-3 fatty acids for the same period.