Genetic evaluation of rs36513 SNP of UIMC1 and Biochemical Parameters in Early Menopause in Babylon City, Iraq
DOI:
https://doi.org/10.37506/ijfmt.v14i4.11868Keywords:
Trans membrane protein, Early menopause, ubiquitin interaction motif.Abstract
Premature menopause or Early menopause (POF) is a condition charecterised by amenorrhea,
hypoesteronigism, and elevated serum gonadotrophin level in women younger than 40 years old. This work
aimed to evaluate the association of candidate genetic polymorphism in called trans membrane protein 150
B (TMEM150B ) and ubiquitin interaction motif containing 1 (UIMC1) also the hormonal changes with
POF in one district of Iraq (province of Babylon) by enrolling Arab ancestors. The genetic variants that
would be studied in this project were carefully selected according to the recent findings in this field, and by
employed several specialized databases . The selected variant are transmembrane protein 150B (TMEM150B
) and ubiquitin interaction motif containing 1 (UIMC1) and their relation with premature ovarian failure.
This study include (200) females , their ages between (35-40 years) and body mass index in normal and
overweight, (50) of them were with amenorrhea for 6 months, and the other (150) apparently healthy as
control group. Concerning rs365132, the genetic association with POF showed that there was no significant
allelic or genotypic association recorded (P > 0.2 ) , except that the patients group was significantly deviated
from Hardy-Weinberg equilibrium exact test (P=0.023). For rs11668344, the genetic association with POF
showed that there was no significant allelic or genotypic association recorded (P > 0.2 ) , except that the
patients group was significantly deviated from Hardy-Weinberg equilibrium exact test (P=0.023). The
hormonal results of the present study showed significant increase in FSH in patients compared with controls
group. (P < 0.0001) and this study showed significant decrease (p? 0.001) in EST in patients compared with
controls group. As a conclusion , the study conclude that rs365132 and rs11668344 genes variants do not
represent genetic factors which can modulate the development of POF in Arab population from Babylon
province .
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