Assessment of Anti-Diabetic Activity of Vinca Rosea Extract on Induced Diabetic Mice

Abstract

Background and Objective: Vinca rosea is a medicinal plant that has been investigated and applied as an
alternative treatment for disorders. This study aimed to investigate the anti-diabetic activity of ethanolic
extract of Vinca rosea on induced diabetes in mice.
Methods: Forty male albino mice were randomly divided into four groups, including control that was
administered a standard physiologic saline and served as control, diabetic group, Streptozotocin & Vinca
rosea, and only Vinca rosea; each group contained ten mice.
Results: No significant lesions were observed in pathological sections of the control; however, the lesions in
diabetic group showed massive lesions in the islets of Langerhans and reduced dimensions of islets due to the
damage of beta-cells. Furthermore, the Pancreas in Streptozotocin & Vinca rosea demonstrated a moderated
vacuolation and Langerhans of islet cells. In contrast, the histopathological sections of the pancreas, which
treated by ethanolic extracts of Vinca rosea, illustrated increasing number of beta-cells hypercellularity. The
values of blood glucose were increased in the diabetic group; however, the significant decreases (P<0.05)
in blood glucose detected in treated by ethanolic extract as represented by increased Beta-cells. While, the
blood glucose levels were tolerated in treated Streptozotocin & Vinca rosea; thus, these values were closely
for the control results.
Conclusion: The Vinca rosea extracts induced a significant impact on diabetic mice, and they can improve
and protect pancreatic cells in diabetic mice. Therefore, ethanolic extracts of Vinca rosea could be beneficial
for the diabetes.