Effect of Methotrexate on Adenosine Deaminase Activity in Rheumatoid Arthritis Iraqi Patients

Abstract

Rheumatoid arthritis (RA) is considered as an autoimmune disease which influences the joints. It usually
results in a warm, enlarged, and painful joints. Stiffness and Pain typically amplify once relaxation.
Frequently, the hands and wrist are involved, with similar joints naturally involved on both sides of the body.
The syndrome might additionally have an impact on the other parts of the body. Adenosine Deaminase is an
enzyme (EC 3.5.4.4) used with the metabolism of purine. It is essential for the analysis of adenosine from
nutrition and the revenue of nucleic acids in soft tissue. Its chief purpose in humans is the immune system
growth and preservation. On the other hand, the complete physiological role of ADA is so far not known.
This study carried out at Al-Kadima Teaching Hospital, during the period fr6-om September 2014 till the
end of October 2015. Patients who have any other disorders conditions are excluded. Subjects accepting
treatment with medications within 7-9 months. A total of 66 patients with Rheumatoid arthritis were
enrolled in this study: thirty-five of them were newly diagnosed to have Rheumatoid arthritis who receives
no therapy for Rheumatoid arthritis (group A); the remaining thirty-one patients were with Rheumatoid
arthritis who receive by methotrexate 500 mg for 7-9 months as the (group B). Twenty-six healthy subjects,
as controls(group C ). The results show a significant elevation in the ADA activity in group A and group B.
The study concluded that the level of ADA was higher in Iraqi RA patients than in healthy control subjects