Solubility and Dissolution Rate Enhancement of Ketoprofen by Nanoparticles

Abstract

Reduction in particles size cause increase in effected surface area of drug particle. So as dissolution
occurred at the surface of solute, rapid increase in dissolution rate due to large surface area. Ketoprofen
belong to class II according Biopharmaceutics Classification System in which has low solubility and high
permeability.the aim of study was to enhance solubility as well as dissolution rate of Ketoprofen when
preparation of Ketoprofen nanoparticles by solvent evaporation method. Different formula of Ketoprofen
nanoparticles were prepared using different type of polymers (pvpk15,HPMCK15, MCA4C,and CMC 30) .
All of the prepared Ketoprofen nanoparticles formulas showed a particle size result within nano-range with
entrapment efficiency ranged from (85.7% to 98.3 %). The average particle size of Ketoprofen nanoparticles
was observed from (55 nm to 995 nm). The selected formula was investigation for DSC, PXRD, FTIR,
SEM, entrapment efficiency and invitro drug release. The invitro dissolution study showed a significant
(p<0.01) enhancement in dissolution rate of nanoparticles formula as compared to pure Ketoprofen (drug a
lone) and physical mixture(drug and stabilizer), at 10 min. 75.7% of drug release from nanoparticles, while
only 15.2%, 22.7% for pure ketoprofen and PM(drug: stabilizer), respectively.