Evaluation The Iron Homeostasis and Erythropoietic Activity in Male Rats with Anemia Related with Induced Chronic Renal Failure

Abstract

The present study conduct to evaluation the iron homeostasis and erythropoietic activity in male rats with
anemia related with induced chronic renal failure. Sixty adult male rats were divided into four groups, the
first group administrate with DMSO as a control negative, while second group administrate DMSO and
then moringa leaf powder, third group adenine were administrated only and fourth group adenine then
given moringaoleifera leaf powder the experiment were lasted for forty-four days. At the end of the study
, blood was collected via the heart puncyure and measured the following biomarkers ( Urea , creatinine ,
BBC count ,Erythropoietinerythoferrone ,, ferritin, Serum iron and hepcidin).The results revealed that the
rats treated adenine caused significant increase in (creatinine ,urea ,ferritin and hepcidin concentration), one
the other hand there was significantly decrease in RBC count ,PVC and HB in adenine group in addition
to Erythropoietin,erythoferrone and serum iron levels , however combined adenine with moringa results in
return these biochemical criteria to their normal levels in control group .