Role of Visfatin and Chemerin in Occurrence and Development of Gestational Diabetes in Pregnant Women

Abstract

A case-control study was carried out in Kirkuk city from March to July 2019. The number of pregnant
women (with gestational diabetes) understudy were 50 whose ages were between 17-42 years old to estimate
the level of visfatin and chemerin in pregnant women with gestational diabetes. These patients attended to
Kirkuk General Hospital to gynecology unit for pregnancy follow up. The control group who were matched
to the pregnant women studied, included 30 healthy non-pregnant women. Blood was collected from each
patient and control enrolled in this study for assessment of HbA1c, blood glucose level, visfatin and chemerin
levels. The study showed no significant difference between studied cases and the control group regarding
patient age and gestational age at sampling and parity (P>0.05) while there was a significant difference
between studied cases and the control group regarding systolic and diastolic blood pressure. The study
showed that the highest mean level of visfatin was found in pregnant women with gestational diabetes
comparing with healthy control ( 14.6±3.11 v.s. 7.81±3.01ng/ml) (P: <0.01). The study showed that the
highest mean level of chemerin was found in pregnant women with gestational diabetes comparing with
healthy control (78.92±18.44 v.s. 78.92±18.44 ng/ml) (P: ?0.05). The study showed that the highest mean
level of visfatin was found in pregnant women who have elevated level of glucose and HbA1c (5.75±3.81
and 5.91±3.67 ng/ml) respectively, as compared with patients with normal level of glucose and HbA1c
(4.61±2.99 and 3.95±2.12 ng/ml) respectively (P: ?0.01). The study showed that the highest mean level
of visfatin was found in pregnant women who have elevated level of glucose and HbA1c (148.9±25.7
and 158.6±23.5 ng/ml) respectively, as compared with patients with normal level of glucose and HbA1c
(111.5±14.6 and 105.1±15.7 ng/ml) respectively (P: ?0.05). The study concluded that, there was a highly
significant relation of visfatin and chemerin with gestational diabetes mellitus in pregnant women