The Intraperitoneal-Ketoprofen-Histopathological Induced Alterations in the Wistar Rat Kidneys

Abstract

The current-focused study was carried out to generate a data profile about expected changes that could be
induced in the kidneys of rats due to the use of intraperitoneal ketoprofen (KP). The study involved using
24 adult male Wistar rats sorted randomly into four groups (six animals per group). One group was treated
as a control group, C, which was supplied with distilled water (DW) only. The remaining animals were
presented as (50KP), (25KP), or (12.5KP) groups that received 50mg/kg.b.w., 25mg/kg.b.w., or 12.5mg/
kg.b.w., respectively, of KP. The experiment was continued for 70 days, and the kidney tissue samples
were collected from the scarified animals at the end of day 70 of that experiment. The kidney tissues of the
50KP animals revealed dilation of the tubules throughout the outer strip of the outer medulla with necrosis
and sloughing of the epithelial cells of the proximal convoluted tubules (PCTs). However, the 25KP group
suffered lesser grades of epithelial-cell sloughing of the PCTs with lower levels of dilation of tubules than
those recorded in the 50KP group. On the other hand, the kidney tissues of the 12.5KP group showed only
dilation in the PCTs. The present experimental data unveil the side effects generated by the use of the
intraperitoneal KP in the examined rat kidneys which should be used as a launching set of information for
better use or further study this drug and its side effects in human patients.