Histomorphological Studies of the Organs of Malaria Mice Model After Administration Combination of Leaf and Stem Bark Extract of Syzygium cumini with Chloroquine

Abstract

This study aims to assess the histomorphological finding of the in spleen, brain, kidneys and lungs organ
in malaria mice model after administration combination of Leaf and Stem bark extract of Syzygium
cumini with chloroquine. Thirty-five male albino mice were randomly assigned into 7 treatment groups.
K0: not infected, K1: infected. K2: infected+chloroquine. P1: infected+Syzygium cumini leaf extract. P2
: infected+chloroquine+Syzygium cumini leaf extract. P3: infected +Syzygium cumini stem bark extract.
P4: infected +chloroquine+ Syzygium cumini stem bark extract. Therapy was given once a day for 4 days
after 24 hours post infection. The 21stday, mice were euthanasia. The organs were taken in order to make
histopathology preparations, stained with hematoxylin and eosin. The combination of Syzygium cumini leaf
extract and chloroquine in mice infected with P. berghei can reduce cerebrum and cerebellum microglia cell
counts, white pulp diameter size, haemorrhages damage, alveolar congestion, edema and thickened alveolar
septa of lung, decreased tubular necrosis, and interstitial nephritis of renal.