Importance of FoxO3 Level in Progression of Nodal Osteoarthritis Disease

Abstract

Objective :To explain a important of Forkhead box O3(FoxO3 ) protein level in progression of Nodal
osteoarthritis (NOA) disease , the location of study at fallujah – Iraq at February 2020 .
Method: Collection of samples take for patients with NOA and controls at Rheumatology & Rehabilitation
Consultation Unit in Al-fallujah Teaching Hospital / Iraq .The Diagnosis NOA patients depended on
American College of Rheumatology (ACR) criteria and used technique of ELISA to measure FoxO3 protein
level.
Results: This study show NOA patient grade 1 have non significant decrease when compare with control
group in FoxO3 protein level ,but observed significant decrease when compare with NOA patient grade 4.
Also show significant decrease when compare NOA patient grade 4 with control group .
Conclusion: This study show that level of FoxO3 protein decrease in NOA cartilage, this lead to reduce of
autophayg and antioxidant proteins .This decrease can result progression of NOA disease .