In Silico Study : Phyllanthus Niruri L as Immunomodulator Against Covid-19

Abstract

In December 2019, a mysterious case of pneumonia was first reported in Wuhan, Hubei Province. The
source of transmission of this case is still unknown, but the first case was linked to the fish market in Wuhan.
From 18 December to 29 December 2019, there were five patients treated with Acute Respiratory Distress
Syndrome (ARDS). 2 From 31 December 2019 to 3 January 2020 this case increased rapidly, marked by 44
cases reported. In less than a month, the disease has spread to other provinces in China, Thailand, Japan and
South Korea. This virus can be transmitted from human to human and has spread widely in China and more
than 190 other countries and territories. On 12 March 2020, WHO announced COVID-19 as a pandemic.
As of March 29, 2020, there were 634,835 cases and 33,106 deaths worldwide. While in Indonesia, 1,528
cases were confirmed with COVID-19 and 136 deaths. Phyllanthus niruri L (meniran) is one type of
immunostimulator that can improve the immune system in animal experiments and humans. This study
aims to determine Phyllanthus niruri L as an immunomodulator for Covid-19. From the results of research
conducted that Phyllanthus niruri L can improve the activities and functions of several non-specific immune
system components and specific immune systems, both soluble and cell-related forms. The conclusion from
the results of this study is Phyllanthus niruri L as an immunomodulator for Covid-19.