Analysis of the Mean Gray Scale and the Mandibular Thickness (Micro-CT) To Mandibular bone Density in Synthetic SCAFFOLD-hADMSC

Abstract

Introduction. The concept of biofactor transplantation in porous and degradable materials as scaffolds is a
place for regenerating new cell and bone tissue growth in the application of tissue engineering. Human Adipose
Derived Mesenchymal Stem Cells (hADMSC) is a multipotent cell which has osteogenic, chondrogenic, and
adipogenic potential. It also has somany similar characteristics with Bone Marrow stem cells (BMSCs) but
hADMSC has higher proliferation rate compared to BMSCs.Inspite of this, another ability of biofactors is
gene engineering. Aim. This study aimed to analyze mandibular bone density from the synthesis of scaffoldhADMSC with the mean gray scale and the mandibular bone thickness (Micro-CT).Material and Methods.
This research involved several processes, namely synthetic scaffold manufacturing process, differentiation
and characterization of hADMSC, and Micro-CT. Results. The results of the marked expression of the
characterization of hADMSCand analysis of the mean gray scale and mandibular thickness (Micro-CT) to
mandibular bone density in synthetic scaffold-hADMSC showed to be significant. Conclusions. Synthetic
scaffold-hADMSC can increase mandibular bone density after Micro-CT analysis.