Forensic Application of ATP6 Gene Haplogroups in a Cohort of Obese Saudis

Authors

  • Sayed A. M. Amer1,2, Abdulaziz S. Asiri3 , Ziad F. Al-Shalaan4 , Ahmed Ch. Kassab1 , Ahmed M. Refaat5

DOI:

https://doi.org/10.37506/ijfmt.v14i4.12160

Keywords:

haplogroups, obesity, ATP6 gene, Saudi Arabian

Abstract

Blood samples from 108 obese individuals (73 males and 35 females) and 106 healthy ones (79 males and
27 females) were collected from a cohort of Saudis inhabiting Riyadh province. ATP6 mitochondrial gene
was amplified and sequenced to identify obesity-related SNPs and the mitochondrial DNA haplogroups for
forensic purposes. A novel site (A8660G) was found while C8655T and T9103C were obesity- related sites.
The haplogroups H2a and H1a were common as they were found in 70.4% and 66% of obese and non-obese
individuals, respectively. L2 was recorded in the obese samples only and H21 was recorded in the obese
males only. The J2a haplohroup was more common in obese individuals. Constructing mtDNA database for
people inhabiting different regions of Saudi Arabia for forensic purpose and to affirm the utility of H21 and
L2 in identifiying obesity is necessary.

Author Biography

  • Sayed A. M. Amer1,2, Abdulaziz S. Asiri3 , Ziad F. Al-Shalaan4 , Ahmed Ch. Kassab1 , Ahmed M. Refaat5

    1
    Department of Forensic Sciences, College of Criminal Justice, Naif Arab University for Security Sciences, 8630,
    Riyadh, Saudi Arabia, 2
    Faculty of Science, Cairo University, Giza, Egypt, 3
    King Fahd Security College, Riyadh,
    Saudi Arabia, 4
    Prince Sultan Medical Millitary City, Riyadh, Saudi Arabia, 5
    College of Biotechnology, Misr
    University for Science and Technology, Egypt

Downloads

Published

2020-10-29

Issue

Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology

Section

Articles

License

https://creativecommons.org/licenses/by-nc/2.0/deed.en

How to Cite

Forensic Application of ATP6 Gene Haplogroups in a Cohort of Obese Saudis. (2020). Indian Journal of Forensic Medicine & Toxicology, 14(4), 3457-3462. https://doi.org/10.37506/ijfmt.v14i4.12160