The Effects of Prenatal Yoga for Primagravida with Gen Expression mRNA FKBP5 (FK506-binding Protein 51)

Abstract

Background: FKBP5 protein plays an important role in determining sensitivity to negative glucocorticoid
feedback, a key mechanism for stopping the HPA axis response in stressful episodes.
Methods: The design of this study is a quasi-experimental approach / quasi experimental and one group
design pre and post test design with group control. The sample in this study amounted to each group of 12
respondents as control and treatment of yoga.
Results: There was a significant difference (p = 0.000 <?) on average FKBP5 gene expression in the control
group before (7.1 ± 0.59) and after observation (9.43 ± 0.68), meaning that there was an increase in cortisol
levels in the control group in the control group before and after observation, while the treatment group
showed a significant difference (p = 0.001 <?), the average expression of FKBP5 gene before being treated
(7.52 ± 0.49) and after being treated (6.88 ± 0.54),
Conclusion: There was a significant difference (p = 0.000 <?) on average FKBP5 gene expression in the
control group, which means that prenatal yoga decreased FKBP5 gene expression before and after treatment.