Antibodies of Double Stranded Deoxyribonucleic Acid and Antinuclear in Patients with Rheumatoid Arthritis: Comparison Study of Seropositive and Seronegative

Abstract

Rheumatoid arthritis is a heterogeneous disease, which can be, based on data combining genetic risk factors
and autoantibodies, sub-classified into positive and negative RA. The present study aims to establish a
comparative analysis between seronegative and seropositive rheumatoid arthritis (RA), with regard to
autoantibodies. A total of 151 patients with rheumatoid arthritis divided into two groups, Group A, 78
patients with seropositive RA and Group B, 73 patients with seronegative RA. The measurements included
ESR, CRP, RF, anti CCP,ANA, and anti dsDNA. Highly significant differences (p ? 0.01) in ESR (31.4 vs
52.8 ml/hr), CRP (10.85 vs 23.59 IU/L), RF (8.34 vs 47.67 IU/L), anti CCP (21.72 vs 41.17IU/L), ANA(
0.92 vs 2.3 IU/L), and anti dsDNA(13.01 vs 29.49 IU/L) levels. Significant correlation of anti dsDNA were
observed with CRP, anti CCP (and ANA in seronegative RA. Meanwhile highly significant correlation were
observed with ESR, CRP, and ANA in seropositive RA. Many of RA-associated autoantibody systems have
been identified and recognize post translationally modified proteins, indicating the immunogenicity of such
proteins for human B cells. Among theme is anti dsDNA which may have a role of the inflammatory process
of RA.