Clinical, Laboratory and Radiologic Evaluations in Patients with Malignant Tuberculous Spondylitis

Abstract

Background: Tuberculous spondylitis patient diagnosis still becomes a challenging task in orthopedics.
Mycobacterium tuberculosis Beijing strain caused malignant tuberculous spondylitis in most patients
(66.7%). Therefore, they proposed scoring system to estimate the prognosis of patients with malignant
tuberculous spondylitis with some parameters, including abscess area, erythrocyte sedimentation rate (ESR),
number of vertebral destruction, disseminated tuberculosis and infectious Mycobacterium tuberculosis stain.
Objectives: To perform clinical, laboratory and radiologic evaluations in patients with malignant tuberculous
spondylitis using scoring system proposed by Yunus and Prijambodo
Methods: This retrospective cohort study was carried out from 2012 to 2015 in patients with malignant
tuberculous spondylitis at Dr. Soetomo Teaching Hospital, Surabaya, Indonesia, using Yunus and Prijambodo
scoring. Subjects were evaluated in minimum 6 months after surgery. The evaluations included clinical
(abscess recurrence), laboratory (ESR) and radiologic (bony fusion in spinal X-ray tomography).
Results: Of eight acute tuberculous patients, only 5 were evaluated. One had moderate prognosis and four
had severe prognosis. No abscess recurrence found in patients after 20-month evaluation. ESR was below
20 mm/hour (12.8±7.8) and 80% of patients had bony fusion in spinal X-ray tomography.
Conclusion: Most patients with malignant tuberculous spondylitis with moderate and severe prognosis
had better outcomes after 20-month evaluation. Further studies should consider other factors affecting
tuberculous spondylitis patient’s prognosis including host factor.