Matrix Metalloproteinases (MMPS) and its Role in Cancers - A Review

Authors

  • J. Aparna1 , M.P. Brundha2

DOI:

https://doi.org/10.37506/ijfmt.v14i4.12407

Keywords:

Matrix metalloproteinases, tumour growth, metastasis, angiogenesis, tumour invasion, matrix

Abstract

The main aim of this study is to analyze the role of Matrix metalloproteinases genes in cancer progression
and metastasis. Matrix metalloproteinase genes were identified in humans, and many are involved in cancer.
Extracellular matrix (ECM) degradation by matrix metalloproteinase not only enhances tumour invasion
but also affects tumour cell behaviour and leads to cancer progression. This review highlights recent
developments in the cellular and molecular mechanisms of matrix metalloproteinase that influence tumour
cell growth, invasion, and metastasis. A review with recent information about matrix metalloproteinases and
its role in cancer collected from search engines from the articles dated from 2000-2020. The recent articles
discussed in this review help to gain knowledge and understanding of Matrix metalloproteinases in cancer
invasion and progression, metastasis, angiogenesis, and aid in the analysis of the mutations caused which
aid the medical field to prevent tumour progression.

Author Biography

  • J. Aparna1 , M.P. Brundha2

    1Research Associate, Dental Research Cell, 2Associate Professor, Department of Pathology, Saveetha Dental
    College and Hospitals, Saveetha Institute of Medical And Technical Sciences, Saveetha University, Chennai,
    Tamilnadu, India

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Published

2020-10-29

Issue

Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology

Section

Articles

License

https://creativecommons.org/licenses/by-nc/2.0/deed.en

How to Cite

Matrix Metalloproteinases (MMPS) and its Role in Cancers - A Review. (2020). Indian Journal of Forensic Medicine & Toxicology, 14(4), 4912-4926. https://doi.org/10.37506/ijfmt.v14i4.12407