IgG4 Related Lung Disorder -A Review

Abstract

IgG4 disorder is an autoimmune disorder. Its manifestation in the lung causes fibroinflammatory disorder.
It is one of the chronic inflammatory disorders. IgG4 is the subclass of IgG. This review is analysed based
on the IgG4 related disorder. Nearly 50 articles were reviewed and this study was conducted for a period of
nearly 15 years.The IgG4 related disorder is a very rare disorder in the world. Moreover, It is an autoimmune
disorder like Systemic lupus erythematosus. It is related to systemic disorder and chronic inflammatory
disorder IgG4 varies high degree of fibrosis and it is prompted by the response of steroid therapy.It is the
most common form of immunoglobulin. Ig G also known as secretory immunoglobulin.Ig G4 is a subclass
of IgG comprising only 4% in gamma immunoglobulins . IgG4 does not bind to polysaccharides. Increased
levels of IgG4 in serum usually found in patients suffering sclerosing pancreatitis, cholangitis and interstitial
pneumonia caused by the infiltration of IgG4 positive plasma cells. IgG4 has a molecular weight of 159.
IgG4 related disorder recognised as one of the rare autoimmune disorders which can affect multiple organs
and cause organ failure sometimes. It involves the complement system and interacts with the antibody.
Generally IgG4 related disorder is recognised as one of the most rare autoimmune disorders which can affect
multiple organ failure sometimes. It involves complement system and interact with antibody. Generally,
IgG4 related disorder most commonly present in in beekeper, animal laboratory workers and individuals
who have undergone allergen immunotherapy possess high serum level of IgG4.it is one of the acquired
Type II hypersensitivity disorder. This review mainly aims to know the reason behind the clinical lung
disorder.