Therapeutic Approach on Oral Mucositis

Abstract

Oral mucositis is a erythematous ulcerated lesion that causes soreness and tissue damage. The lesion leads
to severe pain. It occurs on the comparative of nutrition diet, poor oral hygiene and local and systemic
infections. The pathophysiology of the oral mucositis consists of five phases where initiation phase leads to
injury to the cell. Which leads to activation of transcripts factors which leads to upregulation of inflammatory
cytokines and tissue damage as results in subsequent bacterial colonization and cytokines mediated damages
. The final phase involves healing through signalling and epithelium proliferation. Maintaining good oral
hygiene reduces the severity of the effect and decreases bacteremia . It can be diagnosed by LLLT low
level laser therapy. Also can be treated by growth factors, locally applicable gels immune modulators and
hematopoietic agents Based on the development of clinical and scientific knowledge standard treatment
plan and further research and analysis is needed for management of mucositis. The severity of oral mucositis
also may be controlled by advanced plant based or nano based phytochemicals.