Association of Retn (Rs3219175) Polymorphism with Oscc Progression and Development - An In Silico Study

Abstract

Oral squamous cell carcinoma (OSCC) is more common with 90% of malignant neoplasm in oral cavity.
Multiple factors leading to OSCC like genetic alterations, ?hr???? exposure, micro environmental carcinogens,
premalignant disease like oral epithelial dysplasia, mitochondrial membrane damage and viruses infections
like HPV (human papillomavirus). RETN gene belongs to the family of mouse resistin-like genes. Human
genetic variations are found to influence inter-individual variation observed in disease susceptibilities, drug
response, response to an infectious disease. At the molecular level these sequence variations influence gene
expression, protein production, function, disease susceptibility in particular individuals. The present in silico
study determines the possible association of RETN polymorphism with that of oral squamous cell carcinoma
in different populations. In this study the RETN gene polymorphism rs321975 was analysed in comparison
to the global frequencies. The present study attempts to identify the possible reason for the selection of “A”
allele in the south asian population. Furthermore, genotyping analysis has to be performed in a south Indian
population to ascertain the association between RETN polymorphism (rs3219175) and OSCC.