Association of Clinical Appearance with Histopathological Features in Oral Squamous Cell Carcinoma

Abstract

Oral Squamous Cell Carcinoma (OSCC) is one of the most common malignant epithelial neoplasms affecting
the oral cavity. The clinical appearance of oral cancer is highly variable and includes ulceroproliferative,
ulcerative, leukoplakic and exophytic. These clinical variants can be graded histopathologically to be a well
differentiated, moderately differentiated or poorly differentiated squamous cell carcinoma. The prognosis
of the patients varies based on the histopathological grading. Hence, the aim of the study is to associate the
clinical appearance of OSCC with the histopathological grading. Data was collected after going through
86,000 patients records from June 2019 to April 2020. Total sample size of the study was 44. The data
was exported to SPSS and the variables were verified. Correlation analysis was carried out for the data
tabulated. Highest correlation was seen between ulceroproliferative lesions and well differentiated OSCC
histopathologically. Hence we can conclude that the clinical appearance of OSCC can give us some clue
about its histopathological grade and the study should be extended to a larger sample size in order to give a
more comprehensive outcome.