Correlation Between Highly Sensitive C-Reactive Protein Level in Cases of Preeclampsia with or without Intrauterine-Growth Restriction

Abstract

Background: Preeclampsia is one of hypertensive disorder that affects 4% of pregnant women, the exact
cause cannot be identified and it is one of the major causes of both maternal and fetal morbidity and mortality
, also it puts a burden on perinatal outcome as prematurity and Intrauterine growth restriction.Continuous
search for predictive markers of severe PE is important and can be used to target high risk women for
effective preventive treatment. Aim of study: to evaluate Highly Sensitive C-Reactive Protein role used
as predictive factor for severity of preeclampsia and whether it can be used to predict development of
Intrauterine growth restriction. Patients and methods: this is a cross-sectional study includes 80 pregnant
women with their age 18-35 years , their gestational age range between 32- 40 weeks , admitted to ALZahraa teaching hospital in Najaf, whose diagnosed as PE based on blood pressure measurement and
proteinuria. Full history and clinical examination were performed, venous blood aspirated for each women
for biochemical analysis, Liver functions tests, Renal function tests, Highly Sensitive C- Reactive Protein,
and Doppler ultrasound. Results:The patients divided into those with mild PE and severe PE, with or
without IUGR. No significant difference between the level of Highly Sensitive C-Reactive Protein and the
severity of PE as p value was[0.779], but there is significant difference between the presence of IUGR and
the level of Highly Sensitive C-Reactive Protein when it is? 2mg/L as the p value was[0.020]. Conclusion:
We conclude that Highly Sensitive C-Reactive Protein is not significantly associated with the severity of
Preeclampsia but associated with intra uterine growth restriction