Renal Function Tests in Women with Preeclampsia with and without Intrauterine Growth Restriction

Abstract

Background: The kidney is the most likely to be affected by endothelial injury in patients with preeclampsia,
so assessment of renal function is essential in the evaluation of the pregnant women with preeclampsia. Aim
of the study: to evaluate which test of renal function in preeclamptic patients with and without intrauterine
growth restriction is more useful. Patients and method:150 women in third trimester with preeclampsia
over period of 14 months diagnosed based on measurement of blood pressure and presence of proteinuria
divided into two group : group A those preeclamptic women without feature of intrauterine growth restriction
by ultrasound and Doppler study and group B those with features of intrauterine growth restriction. Blood
aspirated from each woman and blood urea, serum creatinine, serum uric acid, and serum cystatin-C were
measured using spectrophotometer. Results: From 150 women with preeclampsia 120 of them had no
features of intrauterine growth restriction and 30 had some features. Mean maternal age of patients included
was 22±0.3 in group A and 24±0.7 in group B which is not differ statistically while the body mass index
should statistically differences between the two group with P value <0.001. the blood urea, serum creatinine
and serum uric acid levels found to be higher in group B but not reach statistical differences while serum
cystatin C are higher in group B mean 1.23±0.45when compared to group A 1.08±0.97with p value <0.001.
Conclusion:Renal function may be affected more in patients with intrauterine growth restriction and cystatin
C level is more promising marker for renal function in preeeclamptic women.