Experimental Evaluation of Talisadi Suspension for Anti-Histaminic and Anti-Inflammatory Activities in Animal Models
DOI:
https://doi.org/10.37506/ijfmt.v14i4.12629Keywords:
Talisadi Choorna [TC], Anti-Histaminic study, Anti-inflammatory study, Tamak Shwas, Bronchial Asthma, Talisadi Suspension [TS]Abstract
Talisadichoorna is a routinely used formulation among ayurvedic practitioner in disorder of Pranavaha,
Annavaha and Rasavahastrotasvyadhi’s. As choorna has some drawbacks, as a dosage forms talisadichoorna
was converted into a modern dosage form i.e. suspension. It is better than choorna in aspects like ease in
administration, longer shelflife and faster absorption. Standard Operating Procedure was followed for its
preparation. No work was reported regarding its pharmacological action except for anti microbiologicalstudy.
This study aimed to assess its anti inflammatory and antihistaminic actions, which is clinically seen. This
study helped in assessing mode of action of the formulation. The disease Tamak shwas can be correlated
with Bronchial Asthma on the basis of pathology, signs and symptoms. Bronchial Asthma is characterised
by dyspnoea, excessive cough, wheeze, chest tightness etc caused by airway inflammation and increase
bronchial responsiveness. To study antiinflamtoamry activates model selected was “Granuloma pouch
model” using rats as experimental animals. To study antihistaminic activity experimental animal guinea pig
was used and model used was “Protection against histamine induced brochospasm model”. It was evident
that Talisadi Suspension exhibit significant anti-inflammatory and antihistaminic activities.
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