Development of Dose Sipping Technology, a New Design Approach for Improving Drug Delivery of Acyclovir in Pediatric Medication

Abstract

Background: In quest of developing a dosage form having increased focus on the development of novel
technologies which combines the advantages of liquids as easy swallowing with that of solid dosage forms
as storage stability and exact unit dosing as well as taste masking which may improve compliance in children
or elderly, dose sipping technology tends to be a better alternative and hence preferred for the present
experimental part.
Objectives: The aim and objective of the present work are to study one such new design approach (Dose
sipping technology) in order to improve drug delivery of antiviral drugs for pediatric medication.
Method: The proposed dose sipping (DS) administration system consists of Acyclovir drug-loaded pellets
formed by the sequential method, further packed in a system of a drinking straw-like tube closed on the
bottom end by a filter plug called a controller.
Results: Cumulative drug release data for formulated Acyclovir loaded spheres against marketed
Acyclovir tablet using Prototype model forstudyingin-vitro drug release per sip, considering the suction
process,achieved 99.70 % release within 11 minutes as compared to 60 minutes for 99.45% with improved
patient compliance.
Conclusion: Dose Sipping (DS) Technology is a dosage form which combines the advantages of liquids as
easy swallowing with that of solid dosage forms as storage stability and exact unit dosing as well as taste
selection in the patient favorite beverage might improve compliance in children or elderly