Vit D Status and Osteoporosis in Tobacco Consuming Men in Rural Region Surrounding Wardha City, Maharashtra, Central Part of India

Abstract

Background: Awareness towards tobacco consumption has increased and it is well accepted too but will it
help to cease the consumption. With widespread menace of tobacco consumption in developing country like
India, not much data of study is available currently about tobacco consumption and osteoporosis around the
rural region of Wardha a central part of India.
Aim: Vit D status and osteoporosis in tobacco consumers and non consumers.
Objective: To asses influence of tobacco consumption on Sr. Vit D, Sr. ionized Ca, Sr. Phosphate, Sr.
parathyroid hormones the biochemical markers of bone turnover and Bone mineral density in a cohort of
214 healthy men in rural area surrounding Wardha region of Maharashtra.
Design: A cross sectional study
Subjects: 214 healthy men aged around 30-50 years with no disease history were included in the study.
Results: Tobacco consumers had significantly reduced levels of Sr 25 OH Vit D (P<0.02), PTH (P<0.001).
There was no significant difference in Sr ionized Calcium between tobacco consumers and Non tobacco
consumers. We got negative effect of tobacco consumption on Sr Osteocalcin (P<0.01).
Conclusion: Calcium and Vit D metabolism is significantly deranged by habit of tobacco consumption and
cannot be explained by life style factors. Vitamin D- PTH system depression among tobacco consumers
represent a other mechanism for the deleterious effects of tobacco consumption on the bones and contribute
to reported risk of osteoporosis among tobacco consumers.
Sponsorship: Intra mural Grant from DMIMS(DU)