Combination of Misoprostol with Transcervical Foley’s Catheter Compared to Misoprostol Alone for Cervical Ripening at Term and Labour Induction in Tertiary Care Hospital: A Randomized Trial

Abstract

Background:Induction of labour is a very common in obstetrics, for that both mechanical and pharmacological
method used for induction. Mechanical Foley’s with misoprostol is an effective method to cut out course of
labour in safe timely manner, for safe neonatal and maternal outcome.
Aims and Objective: The aim of this study was to compare combination of transcervical Misoprostol with
Foley’s catheter balloon to misoprostol alone for induction of labour and cervical ripening in uncomplicated
pregnancy, with regards to safety and effectiveness.
Result: A prospective, randomized controlled study was conducted on 220 term singleton women admitted
in our hospital for induction of labour were randomly allocated to Group 1 (combination of Foley’s and
misoprostol) and Group 2 means (misoprostol) each 110. Combination of Foley’s and vaginal misoprostol
was much more effective in nulliparous female than multiparous women. Induction delivery interval was
shorter in combination group;14.4±5.70 hours than misoprostol group; 17.1±5.62 hours; p value is 0.007.
Conclusion: This study showed that the use of misoprostol with a trans cervical Foley’s is an effective method
to shorten the course of labour compared with misoprostol alone. This study suggest that combination may
be useful to achieve safe and timely delivery in unripe cervix.