Rasaushadhi (Herbomineral Formulations) Induced Nephrotoxicity in Children: Safety Concern Case Series

Abstract

Background: Use of Rasaushadhi (Herbomineral formulations) in children is sensible topic. In last decade,
some articles reported in various newspapers about nephrotoxicity of Ayurvedicherbomineral medicines.
These issues create negative impression regarding the use of Ayurvedicherbomineral medicines. Ayurveda
itself a time tested life science and provide guidelines to stay healthy and preserve the health. Such articles
have done considerable damage to the reputation of ayurveda but at same time, it has raised many questions
which need to be addressed. To make system more scientific and evidence based study was conducted at
Paediatric department of Government institute in 2017. Paediatric department in this institute has used
Rasaushadhi in children several times and not noted any problem regarding nephrotoxicity till date.
Aim: Question: Does Rasaushadhi (Herbomineral formulations) cause Nephrotoxicity in children? To
determine Rasaushadhi (Herbomineral formulations) is “safe” study was conducted.
Materials and Method: Study was conducted for recurrent and reactive respiratory illness in children and
herbomineral five drugs regimen was given to children of age 4 to 14 years for 45 days at 15 days interval.
To rule out Nephrotoxicity after the use of Ayurvedicherbomineral formulations kidney function test was
done. Patients were clinically observed in 4 follow ups, each follow up was conducted every 15 days. Last
(Fourth) telephonic follow up was taken after six months of completion of treatment course to observe any
renal obstructive pathology.
Results: Total 13 patients of case series were observed normal kidney function test reports. Last (Fourth)
telephonic follow up was also reported normal, no any renal complications reported.
Conclusion: This clinical case series found that use of Ayurvedicherbomineral medicines in paediatric
patients is safe and there is no relation with nephrotoxicity or any obstructive renal pathology when used
properly