Nerve Conduction Study in Early Diagnosed Cases of Hypothyroidism in Central India

Authors

  • Komal Meshram1, Alka Rawekar2, Ajay Meshram3, Harshwardhan Meshram4, Anjali Vaggha5, Shilpa Ingle6

DOI:

https://doi.org/10.37506/ijfmt.v14i4.12760

Keywords:

Nerve conduction study, hypothyroidism, central India

Abstract

Thyroid gland has multiple effects on the neuromuscular system and brain, its dysfunction is associated with
characteristic symptoms and signs with functional alterations in many organs and systems. Thyroid disease
may cause signs and symptoms of neuromuscular dysfunction. Hypothyroidism has been associated with the
clinical features of proximal muscle weakness, mononeuropathy and sensorimotor polyneuropathy.Nerve
conduction studies (NCS) are useful adjunct to the clinical examination of the peripheral nervous system
as it is helpful to test speed of signals through a nerve. They help to delineate the extent and distribution of
the neural lesion and distinguish two major categories of peripheral nerve disease demyelination and axonal
degeneration. Present cross sectional studywas conducted at Central Neurophysiology Laboratory in tertiary
care teaching hospital, J.N.M.C, Sawangi (M), Wardha catering to rural population of central India to assess
the nerve conduction in early diagnosed hypothyroid patients. Total twenty seven patients; 20-50yrs of age
were screened for nerve conduction.In our study we got mixed type of peripheral neuropathy. Out of 27
patients with age 18-30 yrs- 1(16.67%), 31-40 yrs- 13(61.90%) and 41-50 yrs -7 (33.3 %) had abnormal
NCS. Occurrence of neuropathy was more common in female patients 80.95% as compared to male patients
19.05%.Sensory nerve action potential (SNAP) amplitudes and conduction velocity were significantly
reduced (p<0.05) in cases diagnosed as hypothyroidism in median (77%), sural (70%) and ulnar nerves
(33%)as compared to controls.

Author Biography

  • Komal Meshram1, Alka Rawekar2, Ajay Meshram3, Harshwardhan Meshram4, Anjali Vaggha5, Shilpa Ingle6

    1Associate Prof, Dept Physiology, DMMC, Wanadongri, Nagpur, 2Prof, Dept Physiology, DMIMSU (DU)
    Sawangi, Wardha, 3Prof Dept Biochemistry, DMIMSU (DU) Sawangi, Wardha, 43rd Year MBBS Student LTMMC,
    Sion, Mumbai, 5Assistant Prof, Deptbiochemistry, DMIMSU (DU) Sawangi, Wardha, 6Assistant Prof, Dept
    Pharmacology, PDMC, Amravati

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Published

2020-10-29

How to Cite

Nerve Conduction Study in Early Diagnosed Cases of Hypothyroidism in Central India. (2020). Indian Journal of Forensic Medicine & Toxicology, 14(4), 7094-7100. https://doi.org/10.37506/ijfmt.v14i4.12760