Pathogenesis Specifics of Allergic Reactivity in Hypertensive Conditions of Pregnants

Abstract

Introduction: Significant allergic reactions and anaphylactic type cytotoxicity are registered in the
pathogenesis of cell damage in pregnant women with hypertensive conditions. Determining role of
indirect mast cell degranulation and allergic changes in neutrophils during pregnancy that complicated by
preeclampsia, allows to identify the allergic status of the body, which is very importance for improving
the quality of early diagnosis, treatment and prevention. The purpose of the study was to identify the
allergic reactivity of pregnant women suffering from hypertensive disorders and to develop practical
recommendations to improve the quality of early diagnosis.
Materials and Method: We observed 6 group of participants: pregnant women with clear allergy clinic,
uncomplicated preeclampsia, pregnant women with light stage of preeclampsia, latent sensitization, pregnant
women with preeclampsia combined with clear allergy clinic, conditionally healthy pregnant women – 1st
control group, practically healthy non-pregnant women – 2nd control group, practically healthy men – 3rd
control group. Using non-infection allergens, we called different types of allergic reactions and conducted
clinical and allergic examinations, general test of bleed, urine, feces, indirect mast cell degranulation test
and neutrophil alteration test.
Results: Within all control groups, the rate of positive reaction against the allergic agents made up less than
10 percent. In all pregnant women with clear clinical picture of allergies complicated or uncomplicated
preeclampsia, as well as in pregnant women with preeclampsia with latent sensibilization, mast cell
degranulation indexes were 4.5-8.6 times higher than that of control group. Among 90 examined pregnant
women, positive reactions of indirect mast cell degranulation were observed in 204 cases.
Conclusion: In cell damage pathogenesis during preeclampsia, anaphylactic and cytotoxic type allergic
reactions play important role. The positive reactions of indirect mast cell degranulation in pregnant women
with an explicit allergy complicated by preeclampsia is significantly higher than in pregnant women with
preeclampsia with hidden sensitization.