Development and Validation of UV-Spectrophotometric Method for Quantitative Assessment of Metronidazole in the «Metromed® Neo» Solution for Infusion

Abstract

Introduction: Metronidazole is widely used in medicine and issues of quality control of its dosage forms
are relevant. Objective - development and validation of a UV spectrophotometric method for monitoring the
quality of metronidazole in the «Metromed® Neo» solution for infusion.
Materials and Method: The object of the study was a solution for infusion containing metronidazole. The
method used is UV spectrophotometry.
Results: The relative error of the developed UV spectrophotometric method for the quantitative assessment
of metronidazole in the solution for infusion was 1.9%. Validation characteristics of the method are within
acceptable limits.
Conclusion: A UV spectrophotometric technique was developed and validated to assess the quality of
the solution for infusion containing metronidazole. The results of the studies make it possible to use the
developed and validated methodology in assessing the quality of metronidazole.