Morphological Characteristics of Intestinal Vessels of Animals with an Experimental Model of Diabetes Mellitus Type 2 Complicated by Microangiopathy

Abstract

Diabetes mellitus and its complications are considered far from unresolved problems of modern medicine.
An important aspect in solving fundamental problems is experimental research aimed at assessing the state
of change of pathogenetic important key positions in the development of such a formidable complication
of diabetes as angiopathy. On the other hand, surgeons’ great interest in bariatric and metabolic surgery,
as method of surgical treatment of type 2 diabetes mellitus, requires in-depth studies to assess the state
of angiogenic changes in the organs of the gastrointestinal tract, namely in the intestine. The article
describes the morphological changes in the vascular capillary bed in the dynamics of the development of
a new experimental model of diabetes mellitus, namely the chemical method of diabetic angiopathy. The
development of an experimental model of diabetic angiopathy showed the staged nature of the changes in
the form of the initial signs of angiopathy, with perivascular infiltration and edema in the form of congestive
plethora in the flesh until the development of vascular hyalinosis, which indicates the irreversibility of the
processes of pathological transformation. Thus, the results of morphological studies in the dynamics of
modeling of diabetic angiopathy indicate the development of diabetes mellitus with its complication in the
form of microangiopathy.