Clinical and Biological Importance of Micro RNA in the Formation of Women Reproductive Losses

Abstract

Habitual miscarriage is currently one of the most frequent complications of the gestational process, which
is diagnosed in 10-25% of pregnant women. (IuA, 2017) Habitual abortion (miscarriage) - spontaneous
interruption of pregnancy two or more times in a row.
So, high expression of miR133a may mediate a decrease in HLA-G expression at the protein level and
may be implicated in the pathogenesis of habitual miscarriage, since HLA-G provides immune tolerance in
pregnancy49. So, the literature data suggest that microRNA dysregulation may be related to the pathogenesis
of various obstetric complications, but accurate methodological approaches to the diagnosis and prediction
of pregnancy complications using microRNA require further study.