Microhemodynamic Parameters of Cortical Substance of Kidneys at Experimental Hydronephrosis

Abstract

Under conditions of unilateral occlusion of the ureter, the development of microhemodynamic disorders of
the cortical substance of the kidneys was studied both on the damage side and on the contralateral (opposite)
side. It has been established that disorders on the side of occlusion depend on the duration of obstruction
of the lumen of the ureter, which determines the development of tissue hypoxia and violates trophic renal
parenchyma. Dynamically functional disorders of the microvasculature occur at the early (on the 1st, 3rd,
and 5th day), and irreversible changes in the renal parenchyma at the later (on the 14th and 30th day) stages
of the experiment. The contralateral one responds to turning off the function of one kidney by adaptive
restructuring of the microhemocirculatory system, which is manifested by dilatation of microvessels and an
increase in the linear velocity of blood flow in them, which ensures its hyperfunction.