Comparative Analysis of Clinical and Laboratory Parameters and Assessment of Antiretroviral Therapy Effectiveness in HIV-Associated Cryptococcal Meningoencephalitis in the Case of Immune Inflammation Syndrome

Abstract

Cryptococcal meningoencephalitis is an opportunistic mycosis. Earlier in medical practice single cases of
the disease were encountered, now the problem becomes more and more urgent due to the increase in the
HIV infection spread, as persons with impaired immune systems are affected. In most cases, cryptococcosis
refers to HIV-associated diseases. However, today there are unexplored clinical, virologic immunological
aspects of HIV-associated cryptococcosis. The comparative rarity of the multi-organ nature of the lesion,
the lack of objective clinical and laboratory data that allow to timely suspect and confirm a cryptococcal
infection, lead to errors in the diagnosis and treatment of this pathology. The main goal of our work is to
study the prevalence of HIV-associated cryptococcosis, the clinical and laboratory features of HIV-associated
cryptococcosis in patients associated with inflammatory immune restoration syndrome to increase the
diagnosis and treatment efficiency in Uzbekistan