The Effect of Pravastatin Provision on Endotelin-1 Levels in Preeclapmsia’s High Risk Patients

Abstract

Objective: To determine the effect of pravastatin administration on endothelin-1 levels in patients at high
risk of preeclampsia.
Method: There are 70 subjects in this research that consist of 34 subjects with the risk of high preeclampsia
who get aspirin and 36 subjects of research to get Aspirin and Pravastatin. Subjects are given therapy started
the gestational age of 12-19 weeks in 6 days until 36 weeks of pregnancy. Endhotelin-1 levels prior to
administration of therapy compared with the levels of endothelin-1 after the administration of treatment.
Results: The test results show the administration of aspirin or aspirin and Pravastatin is shown to provide the
changes were significant at levels of endothelin-1 after the administration of treatment. It is characterized by
the decrease in the levels of endothelin-1 which were significantly (p <0.005). But by assessing percentage
decrease in the provision of aspirin with pravastatin give change levels of endothelin-1 is large (45.74%)
compared with administration of aspirin alone (28.8%).
Conclusion: From this study it can be concluded that endothelin-1 levels before administration of aspirin
and pravastatin were 86.18 ng/L and after administration of 46.76 ng/L. Giving aspirin and pravastatin 20
mg in patients with high risk factors of preeclampsia provide reduced levels of endothelin-1 is greater than
the prevention of preeclampsia that is used when it is only aspirin.