Pre-Clinical Study of General Toxicity of the Medication “Fitin-S”

Abstract

A pre-clinical study of the general toxicity of the medication “Fitin-S” has shown that it is referred to
class IV of low toxic compounds. The medication “Fitin-S” does not have aaccumulative and local irritant
action. At multiple intramuscular administration to rats and rabbits it does not influence the behavior and the
dynamics of animals growth, does not cause a toxic effect on the composition of peripheral blood, kidneys’
and liver’s function as well as on the pathomorphology of animals organs and tissues. There is a slowdown
in the process of blood coagulation in rabbits at doses of 16 and 32 mg/kg during the whole study period.
In 1 month of a recovery period all the indicators have been changing within physiological norm. All the
aforementioned data allows us to make a conclusion that the medication does not cause a toxic effect on the
organism of animals.