Significance, Effectiveness and Prospects of Development of Enzyme Preparations in Modern Pharmaceutical Practice

Abstract

This article presents topical issues devoted to the study and prospects for the development of enzyme
preparations in modern pharmaceutical practice in the Republic of Uzbekistan. In the context of existing
resources, the rational use of high-quality, effective, safe medicines and the creation of new ones by
combining local raw materials with an innovative approach is a priority. The expediency of combinations of
drugs useful for medical practice for effort or combination of effects is noted.
In medicine, nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat rheumatoid
arthritis and other inflammatory diseases. NSAIDs are the basic drugs in the pharmacotherapy of many
chronic, acute diseases, normalizing biochemical parameters and the functional state of blood cells. These
drugs are taken over-the-counter and for a long time, and therefore resolving issues, related to the safety of
their use, the search for a combination is relevant. Currently, domestic developments of NSAIDs (fensulkal,
blizketazin) are being carried out by combining enzymes (to enhance the effect) and in justified rectal and
transfermal medicinal forms. Many diseases are associated with impaired secondary enzyme deficiency.
Clinical studies confirm the high effectiveness of the combination of NSAIDs with enzyme preparations. The
classification of proteolytic enzymes, the importance, scale and resources of the prevalence of plant enzymes
in the Republic are presented. Of particular interest is the papaya (melon tree). Papain and chymopapain are
latex enzymes of the fruits of the melon tree.