Especially the Development of Myocarditis in Hypothyroidism in Postnatal Ontogenesis

Authors

  • Mirzamukhamedov O.Kh.1, Mirsharopov U.M.2, Sodikova Z.Sh.3, Akhmedova S.M.4, Khatamov A.I.5, Mirzabekova O.A.6

DOI:

https://doi.org/10.37506/ijfmt.v14i4.12868

Keywords:

Heart, myocardium, hypothyroidism, myocytolysis, mexidol.

Abstract

The morphological changes in the myocardium of the offspring were studied when the mother had
hypothyroidism in the rat to the female mother during the feeding of the rats.
The aim of our work was to identify structural and morphological changes in the walls of the heart of baby
rats born to mothers in a state of hypothyroidism and the use of the antioxidant Mexidol.
The material for the experiment, served microscopic myocardial preparations of 50 rats of different periods
of early postnatal ontogenesis.
Results: The morphological structure of the myocardium of the heart of baby rats born to mothers, dystrophic
changes were observed in a state of hypothyroidism. The observed changes reached a maximum by the 14th
day of studies, manifested by perivascular and interstitial lymphohistiocytic infiltrate. Changes should also
occur in the ultrastructure of the heart, which leads to changes in myofibrils, damage to the mitochondria,
which affect the microvessels with a violation of the components of the vascular walls, which are developing
intercellular edema

Author Biography

  • Mirzamukhamedov O.Kh.1, Mirsharopov U.M.2, Sodikova Z.Sh.3, Akhmedova S.M.4, Khatamov A.I.5, Mirzabekova O.A.6

    1PhD, Scientific Researcher, Teaching Assistant, Department of Anatomy, Clinical Anatomy, Tashkent Medical
    Academy, 2 Farobiy Street, Almazar district, Tashkent, Uzbekistan. 100109, 2DSc, Professor, Department of
    Anatomy, Clinical Anatomy, Tashkent Medical Academy, 2 Farobiy Street, Almazar district, Tashkent, Uzbekistan.
    100109, 3DSc, Docent, Department of Anatomy, Clinical Anatomy, Tashkent Medical Academy, 2 Farobiy Street,
    Almazar district, Tashkent, Uzbekistan. 100109, 4DSc, Docent, Department of Anatomy, Clinical Anatomy, Tashkent
    Medical Academy, 2 Farobiy Street, Almazar district, Tashkent, Uzbekistan. 100109, 5DSc, Docent, Department of
    Anatomy, Clinical Anatomy, Tashkent Medical Academy, 2 Farobiy Street, Almazar district, Tashkent, Uzbekistan.
    100109, 6Research scholar, teaching assistant, Department of Retraining and Advanced Training of the General
    Practitioner, Tashkent Medical Academy, 2 Farobiy Street, Almazar district, Tashkent, Uzbekistan. 100109

Downloads

Published

2020-10-29

Issue

Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology

Section

Articles

License

https://creativecommons.org/licenses/by-nc/2.0/deed.en

How to Cite

Especially the Development of Myocarditis in Hypothyroidism in Postnatal Ontogenesis. (2020). Indian Journal of Forensic Medicine & Toxicology, 14(4), 7737-7745. https://doi.org/10.37506/ijfmt.v14i4.12868