Neuroimmunological Characteristics of Idiopathic and Symptomatic Epilepsy in Accordance with the Clinical Course

Abstract

The authors have scientifically determined an immunoreactivity enhancement, which one can indicate by
a change in the level of neurotropic autoantibodies in relation to proteins and neurotransmitter receptors in
epileptogenesis and the formation of aberrant plasticity among patients with symptomatic and idiopathic
epilepsy. Epilepsy is a variant of autoimmune dysregulation, in which an increase in the content of
autoantibodies in relation to neuro-specific proteins and neurotransmitters causes the genesis, progression
and preservation of the pathological process in accordance with the etiological factor.
A new impulse to study the problem of epilepsy immunopathogenesis should be the ideas of in the last
decade about the function inseparable integration of the two main integrative body systems: the central and
the immune nervous systems2. On the basis of information about neuroimmune interaction, new scientific
disciplines — Neuroimmunology and neuroimmunopathology formed5.